Journal Article

Renal, cardiovascular and metabolic effects of fetal programming

N. Koleganova, K. Benz, G. Piecha, E. Ritz and K. Amann

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 27, issue 8, pages 3003-3007
Published in print August 2012 | ISSN: 0931-0509
Published online August 2012 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfs167
Renal, cardiovascular and metabolic effects of fetal programming

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Disturbed fetal development has long-lasting effects on the offspring, specifically a higher risk of renal, cardiovascular and metabolic disease in adult life as postulated by Barker's hypothesis. Relevant to renal outcomes of the offspring are maternal factors such as pre-eclampsia, malnutrition, smoking, drugs etc. The main renal abnormalities in the offspring include reduced nephron number and higher risk of low glomerular filtration rate, albuminuria, hypertension and worse outcome of primary kidney disease. Relevant to renal outcomes is also the predisposition to obesity and type 2 diabetes.

Keywords: heart; intrauterine programming; kidney; metabolism; vasculature

Journal Article.  3002 words.  Illustrated.

Subjects: Nephrology

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