Journal Article

The role of T cells in the pathogenesis of primary hypertension

Yasmir Quiroz, Richard J. Johnson and Bernardo Rodríguez-Iturbe

in Nephrology Dialysis Transplantation

Published on behalf of European Renal Association - European Dialysis and Transplant Assoc

Volume 27, issue suppl_4, pages iv2-iv5
Published in print December 2012 | ISSN: 0931-0509
Published online October 2012 | e-ISSN: 1460-2385 | DOI: http://dx.doi.org/10.1093/ndt/gfs421
The role of T cells in the pathogenesis of primary hypertension

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Accumulating evidence indicates that T cells play an important role in the pathogenesis of hypertension. Here we review the investigations that have shown that T cells are infiltrating the kidney in hypertension. Interstitial accumulation of immune cells is associated with increments in oxidative stress and renal angiotensin II activity that result in the impairment in pressure natriuresis. The severity of salt-sensitive hypertension is directly correlated with the intensity of immune cell infiltration in the kidney. Reducing the renal infiltration of T cells prevents or ameliorates hypertension and the induction of tubulointerstitial inflammation results in salt-sensitive hypertension. The potential participation of autoimmune mechanisms in the renal infiltration of immune competent cells is discussed.

Keywords: renal angiotensin II activity; salt-sensitive hypertension; T cells; tubulointerstial nephritis

Journal Article.  2356 words.  Illustrated.

Subjects: Nephrology

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