Journal Article

Localization of gelatinase-A and gelatinase-B mRNA and protein in human gliomas

Sheetal A. Raithatha, Huong Muzik, N. Barry Rewcastle, Randal N. Johnston, Dylan R. Edwards and Peter A. Forsyth

in Neuro-Oncology

Published on behalf of Society for Neuro-Oncology

Volume 2, issue 3, pages 145-150
Published in print July 2000 | ISSN: 1522-8517
Published online July 2000 | e-ISSN: 1523-5866 | DOI: http://dx.doi.org/10.1093/neuonc/2.3.145
Localization of gelatinase-A and gelatinase-B mRNA and protein in human
gliomas

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Malignant gliomas maintain a poor prognosis and survival rate due to their marked local invasive growth and neovascularization. Matrix metalloproteinases (MMPs) have been implicated in glioma invasion and angiogenesis, but it is unknown whether they are produced by the tumor cells or surrounding stroma. Using in situ hybridization and immunohistochemistry, we found expression of mRNA for both gelatinase-A (MMP2) and gelatinase-B (MMP9) localized to tumor cells and vascular structures in glioma sections. Gelatinase-A protein expression was detected most prominently in tumor cells, with very little signal seen in vasculature. Gelatinase-B protein expression was prominent in vascular structures but was also expressed in tumor cells. Our data show that these proteases are produced by glioma cells and vascular structures and suggest that synthetic MMP inhibitors might be useful in this disease.

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Subjects: Medical Oncology ; Neurology

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