Journal Article

PT-02LONG-TERM SURVIVAL (>20 YEARS) OF A CHILD WITH BRAINSTEM GLIOMA TREATED WITH ANTINEOPLASTONS A10 AND AS2-1: A CASE REPORT

Gregory Burzynski, Tomasz Janicki, Ania Marszalek and Stanislaw Burzynski

in Neuro-Oncology

Published on behalf of Society for Neuro-Oncology

Volume 16, issue suppl_5, pages v175-v175
Published in print November 2014 | ISSN: 1522-8517
Published online November 2014 | e-ISSN: 1523-5866 | DOI: http://dx.doi.org/10.1093/neuonc/nou266.2
PT-02LONG-TERM SURVIVAL (>20 YEARS) OF A CHILD WITH BRAINSTEM GLIOMA TREATED WITH ANTINEOPLASTONS A10 AND AS2-1: A CASE REPORT

More Like This

Show all results sharing these subjects:

  • Medical Oncology
  • Neurology

GO

Show Summary Details

Preview

Tectal glioma is a subtype of midbrain brainstem glioma which occupies the tectum or quadrigeminal plates. The patient generally presents with symptoms related to increased intracranial pressure and requires treatment for hydrocephalus. No effective pharmacological treatments have yet been introduced. This report discusses a case of a 12-year-old male diagnosed with tectal glioma that had the onset of symptoms in November 1993. Initial treatment consisted of the placement of a ventriculoperitoneal shunt. After six years of stabilization of the disease, there had been an increase in the tumor size with signs of malignant transformation. In August 2001, he started treatment with Antineoplaston (ANP) A10 and AS2-1 infusions and continued for 20 months according to Phase II Protocol BT-09. The dosage of A10 was maintained between 12.5 and 14.7 g/kg/d and AS2-1 from 0.3 and 0.4 g/kg/d. He obtained a complete response and was switched to a maintenance study with A10 and AS2-1 capsules (0.26 g/kg/d of each), according to Protocol BT-34. All treatments were discontinued in December 2003. His condition continued to improve during the treatment with ANP and currently, 20 years from his diagnosis and over 12 years from treatment start, he is symptom free and leads a normal, productive life. This report indicates that it is possible to obtain long-term survival of a child with aggressive brainstem glioma with currently available investigational treatment.

Journal Article.  0 words. 

Subjects: Medical Oncology ; Neurology

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.