Journal Article

Assessing behavioral syndromes in patients with brain tumors using the frontal systems behavior scale (FrSBe)

Sergio Cabrera, Kim Edelstein, Warren P. Mason and Maria Carmela Tartaglia

in Neuro-Oncology Practice

Published on behalf of The Society for Neuro-Oncology

Volume 3, issue 2, pages 113-119
Published in print June 2016 | ISSN: 2054-2577
Published online November 2015 | e-ISSN: 2054-2585 | DOI: http://dx.doi.org/10.1093/nop/npv055
Assessing behavioral syndromes in patients with brain tumors using the frontal systems behavior scale (FrSBe)

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  • Medical Oncology
  • Palliative Medicine
  • Clinical Oncology
  • Clinical Radiology
  • Neurosurgery

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Background

Personality changes following brain tumors may be due to disruption of frontal-subcortical networks. The relation between personality changes and tumor parameters such as volumes of the surgical cavity, residual tumor, or nonspecific white matter abnormalities is unknown. In this study we examined the relation between these tumor parameters and abnormal behaviors typically associated with frontal lobe dysfunction.

Methods

Thirty-one patients with intracranial tumors who completed the Frontal Systems Behavior Scale (FrSBe) during clinical neuropsychological assessment and had a solitary, well-delimited brain lesion on MRI within 3 months of that assessment were included. Tumor parameters were manually segmented using OsiriX. Nonparametric statistics were used to determine the relationship between tumor parameters and frontal behavioral dysfunction as measured by FrSBe scores.

Results

Patients reported significantly more behavior problems after tumor diagnosis. Tumor cavity volume was correlated with self-reported Executive Dysfunction (rho = 0.450, P = .047), and there was a trend in the relationship with self-reported Apathy (rho = 0.438, P = .053). Nonspecific white matter abnormality volume was also correlated with self-reported Apathy (rho = 0.810, P = .01). There were no correlations between FrSBe scores and residual tumor volume or summed volumes of tumor-related parameters.

Conclusion

Our results suggest that tumor parameters have differential effects on behaviors associated with frontal-subcortical networks and corroborate the high frequency of behavioral dysfunction in brain tumor patients. Examination of these relationships in a prospective trial is warranted to establish incidence, prevalence, risk factors, and consequences of behavioral disturbances in brain tumor patients.

Keywords: executive function; intracranial tumors; neurocognitive; quality of life

Journal Article.  4532 words.  Illustrated.

Subjects: Medical Oncology ; Palliative Medicine ; Clinical Oncology ; Clinical Radiology ; Neurosurgery

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