Abelson leukaemia virus

Quick Reference

A replication-defective murine leukaemia virus (A-MuLV), a retrovirus, that requires coinfection of cells with a ‘helper’ virus to proliferate and to cause a rapidly progressive lymphosarcoma (the Moloney murine leukaemia virus is often used). The oncogenic effects are due to its acquisition of c-abl, a nonreceptor tyrosine kinase, that has a G-actin binding site and an independent F-actin binding site.

Subjects: Genetics and Genomics — Medicine and Health.

Reference entries