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abrin


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An AB toxin from the seeds of the jequirity bean Abrus precatorius. It is lectin-like, having a binding site for galactose and related residues in carbohydrate, but is monovalent so does not act as an agglutination. The A-chain (ABRaA) has N-glycosylase activity toward eukaryotic 28S rRNA and inhibits protein synthesis. There is no antidote.

Subjects: Chemistry.


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