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The introduction of an acetyl group (CH3CO–) into a compound. The acetylation of coenzyme A to acetyl coenzyme A is an important stage in the Krebs cycle: the acetyl group is derived from pyruvate after the removal of a molecule of carbon dioxide and two hydrogen atoms. Acetylation of histone proteins in chromosomes tends to activate genes. See chromatin silencing.

Subjects: Biological Sciences.

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