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The major surface protein (639 aa) of Listeria monocytogenes that spans both the bacterial membrane and the peptidoglycan cell wall. Once the bacterium is within the host cell ActA serves as a nucleating site for the Arp2/3-mediated assembly of a ‘comet tail’ of microfilaments from one pole, pushing the bacterium through the cytoplasm. A functionally similar protein, IcsA, is found in Shigella.

Subjects: Medicine and Health.

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