acute-phase response

'acute-phase response' can also refer to...

acute-phase response

acute-phase response

Acute-phase responses and adipocytokines

The acute phase response in panic disorder

The acute phase response and C-reactive protein

Determinants of the acute phase response in acute myocardial infarction

Acute phase responses following minimal access and conventional thoracic surgery

Liver Genomic Responses to Ciguatoxin: Evidence for Activation of Phase I and Phase II Detoxification Pathways following an Acute Hypothermic Response in Mice

Reduced complement activation during cardiopulmonary bypass does not affect the postoperative acute phase response

Net effect of an acute phase response—Partial alleviation with probiotic supplementation

Increased sialylation and defucosylation of plasma proteins are early events in the acute phase response

Gene Expression Analysis of the Acute Phase Response Using a Canine Microarray

Menstrual Phase and Depressive Symptoms Differences in Physiological Response to Nicotine Following Acute Smoking Abstinence

The acute phase response in chronic haemodialysis patients: a marker of cardiovascular disease?

Osteoclastic bone resorption in rheumatoid arthritis and the acute-phase response

Regulation of low-density lipoprotein cholesterol by intestinal inflammation and the acute phase response

Acute Phase Response Detection and Quantitation at the Point of Care in Older Adults With Acute Bacterial Infections

The Acute-Phase Response and Serum Amyloid A Inhibit the Inflammatory Response to Acinetobacter baumannii Pneumonia

Diminished Acute Phase Response and Increased Hepatic Inflammation of Aged Rats in Response to Intraperitoneal Injection of Lipopolysaccharide


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A mechanism of innate immunity in which the liver markedly increases its synthesis of certain immune proteins, the acute-phase proteins, in response to infection. This change in protein output by liver cells is triggered by tumour necrosis factor α (TNF-α), interleukin-1 (IL-1), and IL-6, which are released by macrophages following their activation as a result of contact with bacteria or other pathogens. The main acute-phase proteins are C-reactive protein and mannose-binding lectin. These behave like antibodies but are nonspecific and bind to a much broader range of targets. Their binding sites attach to surface components of bacteria and fungi, making them more susceptible to ingestion by phagocytic cells (see opsonization); they also activate the complement system of immune proteins, which initiates destruction of the targeted cell.

Subjects: Biological Sciences.

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