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ADAM family


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A family (a disintegrin and metalloprotease family) of membrane-anchored peptidases that cleave proteins of the cell surface and extracellular matrix (ECM) and may release membrane-bound growth factors. Examples include α-*secretase, fertilin, and TACE. A similar and related family (with at least nineteen members) are the ADAM metallopeptidases with thrombospondin type 1 motif (ADAMTSs) that are thought to be anchored to ECM through interaction of the thrombospondin motif with aggrecan or other matrix components. ADAMTS-2, -3, and -14 process the N-peptide of procollagens I, II and III. Mutations in ADAMTS2 are associated with Ehlers–Danlos syndrome VIIC, ADAMTS10 mutations with Weill–Marchesani syndrome. Mutation in ADAMTS-like 2 is associated with geleophysic dysplasia. See punctin (ADAMTS1 and 3).

Subjects: Medicine and Health.


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