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adenine nucleotide translocator


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One of the solute carrier family of proteins (ANT, ADP/ATP translocator, SLC25A4), the most abundant mitochondrial protein, a homodimer of 298 aa subunits embedded asymmetrically in the inner mitochondrial membrane that forms a gated pore through which ADP is moved from the matrix into the cytoplasm. Mutations in this gene lead to progressive external ophthalmoplegia type A2.

Subjects: Medicine and Health.


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