A hypotensive vasodilator peptide (ADM, 52 aa) found in blood in significant amounts. It has diuretic and natriuretic effects on the kidney where it inhibits aldosterone secretion and in the pituitary it inhibits basal ACTH secretion. Together with adrenomedullin-binding protein-1 (AMBP-1) it has been shown to reduce tissue damage in inflammation and appears to protect cells against oxidative stress. Adrenomedullin-2 (intermedin, 148 aa) may regulate gastrointestinal and cardiovascular activities through a cAMP-dependent pathway. The receptor is G-protein coupled. See proadrenomedullin.
Subjects: Medicine and Health.