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A protein target (AF-6 protein, 1816 aa) of ras that regulates cell–cell adhesions (zonula adherens junctions) and is involved in the linkage of microfilaments to nectins. It is fused with MLL in leukaemias caused by t(6;11) translocations. Interacts with Eph-related receptor tyrosine kinases.

Subjects: Medicine and Health.

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