The major structural proteoglycan of cartilage, the core protein (2316 aa) to which ~100 chondroitin sulphate chains and several keratan sulphate chains as well as O- and N-linked oligosaccharide chains are linked. It binds to a link protein (~40 kDa) and to hyaluronic acid to produce very large multimolecular aggregates. A mutation in aggrecan leads to Kimberley type spondyloepiphyseal dysplasia. The linker domain between the N-terminal globular domains is highly sensitive to proteolysis by aggrecanases, peptidases of the ADAM family.
http://www.glycoforum.gr.jp/science/word/proteoglycan/PGA03E.html Structure and function of aggrecan and versican.
Subjects: Medicine and Health — Chemistry.