A family of serine/threonine kinases activated by PI-3-kinase downstream of insulin and other growth factor receptors. It is the product of the cellular homologue of v-akt, the transforming oncogene of AKT8 virus. Akt will phosphorylate glycogen synthase kinase (GSK3) and is involved in stimulation of Ras and control of cell survival. Three members of the Akt/PKB family have been identified: Akt1 (PKBα, EC 18.104.22.168, 480 aa), Akt2 (PKBβ, 481 aa), and Akt3 (PKBγ, 479 aa). Akt2 has been associated with ovarian carcinomas.
Subjects: Medicine and Health.