aldose reductase

Quick Reference

One of the monomeric, NADPH-dependent aldoketoreductase family of enzymes (aldehyde reductase 1, EC1.1.1.21, 316 aa) involved in glucose metabolism and osmoregulation. It is the first and rate-limiting enzyme of the polyol pathway of sugar metabolism, has a role in protecting against toxic aldehydes derived from lipid peroxidation and steroidogenesis, and has been implicated in diabetic complications.

Subjects: Medicine and Health.

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