Alexander disease

'Alexander disease' can also refer to...

Alexander's disease

Alexander disease

Adult-onset Alexander disease: a series of eleven unrelated cases with review of the literature

Suppression of GFAP toxicity by αB-crystallin in mouse models of Alexander disease

Alexander Mercer, Infections, Chronic Disease, and the Epidemiological Transition. A New Perspective

Alexander B. Bay, Beriberi in Modern Japan: The Making of a National Disease

Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways

BREMNER, Alexander (1890 - 1944), Hon. Physician Children’s Hospital, Sheffield; Lecturer, Diseases of Children, Sheffield University

ROCHE, Alexander Ernest (1896 - 1963), late Consulting Surgeon; Speciality Diseases of the Urinary Organs; Surgeon-in-Charge of the Genito-Urinary Dept, West London, Royal Northern and Hounslow Hospitals

PLATTS-MILLS, Thomas Alexander (born 1941), Professor of Medicine, Head of Division of Allergy and Clinical Immunology, and Head of Asthma and Allergic Diseases, University of Virginia, since 1982

PETO, Timothy Edward Alexander (born 1950), Professor of Medicine, University of Oxford, since 1999; Consultant Physician in Infectious Diseases and General Medicine, John Radcliffe Hospital, since 1988

DRAKE, John Alexander (1878 - 1952), Consulting Physician for Diseases of the Skin, King’s College Hospital, London; late Dean, King’s College Hospital Medical School

BLACKADER, Alexander Dougall (1847 - 1932), Emeritus Professor of Pharmacology, Therapeutics, and Pediatrics, McGill University, Montreal; late Editor Journal Canadian Medical Association; President of the Alexandra Hospital for Infectious Diseases; Medical Adviser to Bank of Montreal

GEDDES, Alexander MacIntosh (born 1934), Professor of Infection, 1991–99, and Deputy Dean, Faculty of Medicine and Dentistry, 1994–99, University of Birmingham (Professor of Infectious Diseases, 1982–91; Associate Dean, 1999–2002)

MORRIS, Malcolm Alexander (1849 - 1924), Chairman of British Federation of Medical and Allied Services; President of Institute of Hygiene; Vice-President of National Council for Combating Venereal Diseases; Member of Committee of Radium Institute

PALMER, Alexander Croydon (1887 - 1963), Cons. Gynæcological and Obstetric Surgeon, King’s College Hospital; Surgeon, Samaritan Free Hospital; Hon. Consulting Gynæcologist to Epsom and Ewell Cottage Hospital, Sutton and Cheam General Hospital, and to Jewish Maternity Home, Underwood Street, E; Examiner in Midwifery and Diseases of Women, University of London; late senior Examiner in Midwifery and Diseases of Women, Conjoint Board London, Oxford University; External Examiner in Midwifery and Diseases of Women, Birmingham Univ

Zoonoses: Infectious Diseases Transmissible from Animals to Humans, 3rd Edition By Hartmut Krauss, Albert Weber, Max Appel, Burkhard Enders, Henry D. Isenberg, Hans G. Schiefer, Werner Slenczka, Alexander von Graevenitz, and Horst Zahner Washington, D.C.: American Society for Microbiology Press, 2003. 456 pp., illustrated. $79.95 (cloth)

KENNEDY, Alexander (1909 - 1960), Professor of Psychological Medicine, University of Edinburgh, since 1955; Physician to Royal Infirmary, Edinburgh, and Clinical Director Royal Edinburgh Hospital for Mental and Nervous Diseases; Psychiatric Adviser and Clinical Director for Research to SE Scotland Regional Hosp. Bd; Pres. Alfred Adler Medical Soc.; Pres. Scottish Assoc. of Psychiatric Social Workers; Vice-President: Eugenics Soc.; Roy. Medico-Psychological Assoc.; Lebanon Hospital, Beirut; Hon. Member Australasian Assoc. of Psychiatrists; Mem. Roy. Soc. of Health; Pres. International Medical Commission on Boxing; FRSoc.Med


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Rare and usually fatal neurodegenerative disorder characterized by the development of megalencephaly in infancy accompanied by progressive spasticity and dementia. The features are similar to those of Canavan's disease. It is caused by a mutation in the glial fibrillary acidic protein (GFAP) gene. Astrocytes in Alexander's disease have protein aggregates (Rosenthal fibres) containing (alpha B-crystallin, heat shock protein 27, and GFAP.

Subjects: Chemistry — Medicine and Health.

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