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Aliskiren, ALTITUDE, and the implications for ATMOSPHERE

Diabetes, aliskiren, and heart failure: let's bring ASTRONAUT down to earth

Aliskiren/Amlodipine vs. Aliskiren/Hydrochlorothiazide in Hypertension: Indirect Meta-Analysis of Trials Comparing the Two Combinations vs. Monotherapy

Neurohumoral effects of the new orally active renin inhibitor, aliskiren, in chronic heart failure

Aliskiren vs. Angiotensin Receptor Blockers in Hypertension: Meta-Analysis of Randomized Controlled Trials

P080 The Protective Effects of Aliskiren on Lung Histopathology after Triolein-Induced Fat Embolism

Aliskiren reduces sympathetic nerve activity and blood pressure in chronic kidney disease patients

Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study

Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design

Aliskiren improves insulin resistance and ameliorates diabetic vascular complications in db/db mice

Differential Effects of Aliskiren/Amlodipine Combination and High-Dose Amlodipine Monotherapy on Endothelial Function in Elderly Hypertensive Patients

Determination of Aliskiren in Tablet Dosage Forms by a Validated Stability-indicating RP-LC Method

A Validated LC Method for the Determination of the Enantiomeric Purity of Aliskiren Hemifumarate in Bulk Drug Samples

Simultaneous Determination of Aliskiren Hemifumarate, Amlodipine Besylate and Hydrochlorothiazide in Spiked Human Plasma Using UPLC-MS/MS

Rationale and design of the multicentre, randomized, double-blind, placebo-controlled Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT)

Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized for heart failure: insights from the ASTRONAUT trial

Aliskiren alone or with other antihypertensives in the elderly with borderline and stage 1 hypertension: the APOLLO trial

P077 Aliskiren, a Direct Renin Inhibitor, Reduces Mast Cell Accumulation in Lungs of Rats After Fat Embolism


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Quick Reference

The first renin inhibitor developed; used to treat essential hypertension. Crystal structure analyses of renin–inhibitor complexes combined with computational methods were used in the design process. TNs Rasilez, Tekturna.

Subjects: Clinical Pharmacology and Therapeutics.

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