The production of nearly normal phenotype in an organism carrying two different mutant alleles in trans configuration. Such complementation is sometimes caused by the reconstruction in the cytoplasm of a functional protein from the inactive products of the two alleles. When such a phenomenon can be demonstrated by mixing extracts from individuals homozygous for each allele, the term in vitro complementation is used. Synonymous with intra-allelic complementation. See Chronology, 1963, Schlesinger and Levinthal; alcohol dehydrogenase, alkaline phosphatase, transvection.
Subjects: Genetics and Genomics.