allelic complementation

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The production of nearly normal phenotype in an organism carrying two different mutant alleles in trans configuration. Such complementation is sometimes caused by the reconstruction in the cytoplasm of a functional protein from the inactive products of the two alleles. When such a phenomenon can be demonstrated by mixing extracts from individuals homozygous for each allele, the term in vitro complementation is used. Synonymous with intra-allelic complementation. See Chronology, 1963, Schlesinger and Levinthal; alcohol dehydrogenase, alkaline phosphatase, transvection.

Subjects: Genetics and Genomics.

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