A compound causing the substitution of an alkyl group (usually methyl or ethyl) for an active hydrogen atom in an organic compound. According to the number of reactive groups they contain, alkylating agents are classified as mono-, bi-, or polyfunctional. Many chemical mutagens are alkylating agents. See busulfan, chlorambucil, cyclophosphamide, epoxide, ethylmethane sulfonate, melphalan, Myleran, nitrogen mustard, sulfur mustard, TEM, Thio-tepa, triethylenethiophosphoramide.
Subjects: Genetics and Genomics — Medicine and Health.