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alkylating drug


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A cytotoxic drug that damages DNA: the addition of alkyl groups to guanine can lead to fragmentation during frustrated repair; nucleotides may be cross-bridged, blocking strand separation; mispairing can cause mutation during replication. There are six groups of alkylating agents: nitrogen mustards, ethylenimes, alkylsulphonates, triazenes, piperazines, and nitrosureas. Examples include cyclophosphamide, dacarbazine, ifosfamide, procarbazine, and temozolomide.

Subjects: Clinical Pharmacology and Therapeutics.


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