Overview

alteration enzyme


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A protein of phage T4 that is injected into a host bacterium along with the phage DNA; this protein modifies host RNA polymerase by linking it to ADP-ribose. RNA polymerase modified in this way renders it incapable of binding to sigma factor and thus unable to initiate transcription at host promoters. See RNA polymerase.

Subjects: Genetics and Genomics.


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