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Alu


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1. A type II restriction endonuclease, isolated from Arthrobacter luteus.

2. Highly repetitive short repeat sequences (Alu repeats, short interspersed elements, SINEs) found in large numbers (100 000–500 000) in the human genome, the most abundant mobile elements (retrotransposons) in the human genome. They were first identified because they were cleaved by the Alu endonuclease. The progenitor of the human Alu repeat may be 7SL RNA, a component of the signal recognition particle. They are useful markers in genomic studies because individuals will only share a particular Alu sequence insertion if they have a common sexual ancestor. Compare long interspersed nucleotide element.

http://batzerlab.lsu.edu/Publications/Batzer%20and%20Deininger%202002%20Nature%20Reviews%20Genetics.pdf Review on Alu repeats; Nature May 2002.

Subjects: Medicine and Health.


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