amiloride-sensitive sodium channels

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A family of voltage-insensitive sodium-permeable ion channels that are inhibited by amiloride (compare voltage-gated sodium channels). In epithelia they constitute the rate-limiting step for sodium ion reabsorption. They are heterotrimers of highly homologous α, β, and γ subunits which also have homology with degenerins. Gain-of-function mutations in the β or γ subunits cause Liddle's disease. A δ subunit that will assemble with the β and γ subunits to form a functional channel is also known and is expressed mainly in ovary, testis, pancreas, and brain. See Apx/Shrm domains.

Subjects: Medicine and Health.

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