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aminopurine


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aminopurine

aminopurine

Synthesis and Hydrolysis of Oligodeoxyribonucleotides Containing 2-Aminopurine

Association of an RNA kissing complex analyzed using 2-aminopurine fluorescence

G-quadruplex structure and stability illuminated by 2-aminopurine phasor plots

Properties of triple helices formed by parallel-stranded hairpins containing 8-aminopurines

Probing dynamics of HIV-1 nucleocapsid protein/target hexanucleotide complexes by 2-aminopurine

Nucleotide flipping by restriction enzymes analyzed by 2-aminopurine steady-state fluorescence

Unusual 2‐aminopurine fluorescence from a complex of DNA and the EcoKI methyltransferase

2-Aminopurine as a fluorescent probe for DNA base flipping by methyltransferases

Synthesis and antiviral evaluation of 7-fluoro-7-deaza-2-aminopurine nucleoside derivatives

Steady‐state and time‐resolved fluorescence studies indicate an unusual conformation of 2‐aminopurine within ATAT and TATA duplex DNA sequences

Triple-helix formation in the antiparallel binding motif of oligodeoxynucleotides containing N9- and N7-2-aminopurine deoxynucleosides

Formation of an intramolecular triple‐stranded DNA structure monitored by fluorescence of 2‐aminopurine or 6‐methylisoxanthopterin

2-Aminopurine fluorescence studies of base stacking interactions at abasic sites in DNA: metal-ion and base sequence effects

Time-resolved fluorescence of 2-aminopurine as a probe of base flipping in M.HhaI–DNA complexes

8-vinyl-deoxyadenosine, an alternative fluorescent nucleoside analog to 2′-deoxyribosyl-2-aminopurine with improved properties

Fluorescence of 2-aminopurine reveals rapid conformational changes in the RB69 DNA polymerase-primer/template complexes upon binding and incorporation of matched deoxynucleoside triphosphates

 

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2-aminopurine (2-AP) is a fluorescent analog of adenine (6-aminopurine). The fluorescence of 2-AP ia quenched once it is incorporated into the base-stacked structure of dsDNA. However, if the base stacking or base pairing of DNA is locally perturbed, the fluorescence of 2-AP is enhanced. Therefore the intensity of fluorescence emissions by 2-AP molecules can be used to monitor perturbations in DNA structure caused by interactions between DNA and proteins, such as DNA polymerase, helicase, and methyl transferase.

Subjects: Genetics and Genomics.


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