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A high mobility group protein (HMGB1, 215 aa) considered a structural protein in chromatin. It can be released from endotoxin or cytokine-stimulated macrophages and is toxic (levels are high in patients with sepsis). It is bound by RAGE (receptor for advanced glycation end products ) and inhibition of the RAGE–amphoterin interaction suppresses various systems linked to tumour proliferation, invasion, and expression of matrix metalloproteinases.

Subjects: Medicine and Health.

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