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amplicon


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A segment of the genome that forms multiple linear copies after exposure of the organism to a compound that inhibits the functioning of a gene in the segment. For example, in mammals the enzyme dihydrofolate reductase (q.v.) is inhibited by methotrexate (q.v.). Exposure to this inhibitor causes amplification of the DHFR gene. More generally, the term amplicons is used for DNA fragments that have been generated in experiments utilizing the polymerase chain reaction (q.v.).

Subjects: Genetics and Genomics.


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