anchorage dependence

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The phenomenon exhibited by many normal cells in culture which require attachment to a solid substratum in order to spread and grow. Spreading may be necessary in order to absorb rate-limiting growth factors from the culture medium. Loss of anchorage dependence is associated with independence from external growth control, and the ability to grow in soft agar (or suspension) is a good predictor of tumorigenicity in vivo.

Subjects: Medicine and Health.

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