Members of the vascular endothelial growth factor family that have effects on blood vessels. Angiopoietin-1 (498 aa) is the ligand for the endothelium-specific receptor tyrosine kinase Tie2; angiopoietin-2 (496 aa) is a natural antagonist. Angiopoietin-4 (406 aa) is induced in endothelial cells by hypoxia and may have a protective function. It inhibits proliferation, migration, and tubule formation by endothelial cells, reduces vascular leakage and is involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. Various angiopoietin-like proteins are also known with miscellaneous tissue-specific functions. Not all are mitogenic for endothelial cells.
Subjects: Medicine and Health — Chemistry.