The dipeptidyl carboxypeptidase (ACE1, EC 18.104.22.168, 1306 aa) that converts angiotensin I into the biologically active form, angiotensin II. Angiotensin converting enzyme 2 (ACE2, EC 3.4.17.-, 805 aa) is a carboxypeptidase which converts angiotensin I to angiotensin 1–9, a peptide of unknown function, and angiotensin II to angiotensin 1–7, a vasodilator. Polymorphisms in ACE1 are associated with susceptibility to ischaemic stroke and diabetic nephropathy and mutations can cause renal tubular dysgenesis. Angiotensin converting enzyme inhibitors (ACE inhibitors) such as captopril and enalapril are used in the treatment of hypertension and heart failure.
Subjects: Medicine and Health — Chemistry.