antigen variation

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'antigen variation' can also refer to...

antigenic variation

antigenic variation

antigen variation

antigenic variation

antigenic variation

antigen variation

Microbial antigenic variation mediated by homologous DNA recombination

Immunogenic protein variations of Clostridium chauvoei cellular antigens associated with the culture growth phase

O-antigen structural variation: mechanisms and possible roles in animal/plant–microbe interactions

Adaptive surface antigen variation in Mycoplasma bovis to the host immune response

Mycobacterium tuberculosis/HIV-1 Coinfection and Disease: Role of Human Leukocyte Antigen Variation

Effects of Sex, Parity, and Sequence Variation on Seroreactivity to Candidate Pregnancy Malaria Vaccine Antigens

Plasmodium falciparum Antigenic Variation: Relationships between In Vivo Selection, Acquired Antibody Response, and Disease Severity

Distinct roles for two RAD51-related genes in Trypanosoma brucei antigenic variation

varDB: a pathogen-specific sequence database of protein families involved in antigenic variation

Antigenicity and recombination of VlsE, the antigenic variation protein of Borrelia burgdorferi, in rabbits, a host putatively resistant to long-term infection with this spirochete

O-antigen structure of Shigella flexneri serotype Yv and effect of the lpt-O gene variation on phosphoethanolamine modification of S. flexneri O-antigens

The rate of antigenic variation in fly-transmitted and syringe-passaged infections of Trypanosoma brucei

Variation in Plasma RNA Levels, CD4 Cell Counts, and p24 Antigen Levels in Clinically Stable Men with Human Immunodeficiency Virus Infection


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Quick Reference

The sequential expression of a series of variable surface glycoproteins (VSGs) by trypanosomes while in the bloodstream of a mammalian host. The production of VSGs allows the parasite to evade the immune defenses of the host by keeping one step ahead of the antibodies the host raises against them. Trypanosomes contain hundreds of different genes for the individual VSGs, but in a single trypanosome only one of these genes is expressed at a given time. The switch from one VSG to another is accompanied by rearrangements of the DNA that generates additional copies of the genes being expressed. The glycoprotein being synthesized forms a macromolecular coating about 15 nanometers thick over the body and flagellum of the parasite. This coating functions only during the mammalian stage of the life cycle, since it is shed when the trypanosome enters the tsetse fly vector. See Glossina, Trypanosoma.

Subjects: Genetics and Genomics.

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