A class of genes (also called tumor suppressor genes) that are involved in the negative regulation of normal growth. The loss of these genes or their products leads to malignant growth. The Rb gene of humans is an example of an anti-oncogene. See Chronology, 1969, Harris et al.; 1971, Knudson; 1990, Baker et al.; breast cancer susceptibility genes, retinoblastoma, TP53, Wilms tumor.
Subjects: Genetics and Genomics.