antioxidant paradox

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Although epidemiological studies show a protective effect of antioxidant nutrients against cardiovascular disease and cancer, intervention trials with vitamin E and carotene have generally shown increased mortality. One explanation is that antioxidants act by forming relatively stable radicals that persist long enough to undergo reaction to non-radical products; they are therefore also capable of perpetuating radical damage deeper into tissues and plasma lipoproteins.

Subjects: Medicine and Health.

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