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1. A family of cis-acting transcription activators often expressed in the same cell lineages but at different times or sites in the developing embryo. All bind to the same consensus sequence in DNA. Mutations in AP2-alpha (436 aa) cause branchiooculofacial syndrome. AP2-beta and -gamma bind to the same DNA consensus sequence; AP2-beta (460 aa) is involved in control of differentiation of neuroectodermally derived cells and is mutated in Char's syndrome; AP2-gamma (450 aa) and AP2-delta (452 aa) are also known.

2. See adaptor proteins.

Subjects: Medicine and Health.

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