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A regulatory protein that, when bound to another molecule (corepressor, q.v.), undergoes an allosteric transformation that allows it to combine with an operator locus and inhibit transcription of genes in an operon. For example, in the histidine system of E. coli, excess histidine functions as corepressor by binding to an aporepressor to form a functional repressor (holorepressor); the holorepressor binds to the histidine operator and inhibits transcription of ten genes of this operon.

Subjects: Genetics and Genomics.

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