apolipoprotein A

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Apolipoprotein A1 (ApoA1, 243 aa) is the major apoprotein of high-density lipoprotein (HDL) and a relatively abundant plasma protein (1.0–1.5 mg/mL). Defects in ApoA1 cause autosomal dominant high density lipoprotein deficiency type 2 (HDLD2, familial hypoalphalipoproteinaemia), and recessive HDLD1 (analphalipoproteinaemia, Tangier disease) (TGD). Defects can also cause amyloid polyneuropathy–nephropathy Iowa type (van Allen type amyloidosis, familial amyloid polyneuropathy type III) and amyloidosis type 8 (systemic non-neuropathic amyloidosis, Ostertag-type amyloidosis). Apolipoprotein A2 (100 aa) may stabilize HDL structure. ApoA4 is a component of chylomicrons and high-density lipoproteins. Defects in ApoA5 cause susceptibility to familial hypertriglyceridaemia and hyperlipoproteinaemia type 5. ApoA1 binding protein (288 aa) interacts with both ApoA1 and ApoA2. Apolipoprotein L1 interacts with ApoA1. Apolipoprotein(a) is the main constituent of lipoprotein(a).

Subjects: Medicine and Health — Chemistry.

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