apolipoprotein B

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The main apolipoprotein of chylomicrons and low-density lipoproteins (LDL). There are two main forms in plasma, ApoB48 synthesized by the gut, and ApoB100 produced by the liver, although both are coded by the same gene differently spliced. Familial hypobetalipoproteinaemia (FHBL) is an autosomal dominant disorder of lipid metabolism in which there are very low plasma levels of apolipoprotein B although triglyceride levels are normal (in contrast to abetalipoproteinaemia due to microsomal triglyceride transfer protein deficiency, Bassen–Kornzweig syndrome or acanthocytosis).

Subjects: Medicine and Health — Chemistry.

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