apolipoprotein H

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A multifunctional apolipoprotein (β2-glycoprotein I, 345 aa) that binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulphate and may prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells. The ApoH–phospholipid complex appears to the autoantigen in some cases of systemic lupus erythematosus and in antiphospholipid syndrome.

Subjects: Medicine and Health — Chemistry.

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