Overview

apoptosome


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A multiprotein complex, the formation of which is triggered by cytochrome c released from mitochondria which binds Apaf-1. The cytochrome-Apaf complex then recruits procaspase-9 which, when activated, starts the caspase cascade. XIAP binds to the caspase 9 and inhibits further proteolytic activity.

Subjects: Medicine and Health — Chemistry.


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