argonaute proteins

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Proteins (eukaryotic translation initiation factors 2C1–4, argonaute 1–4, AGO1–4, ~857 aa) that are concentrated in GW bodies and are key components of RNA-induced silencing complexes (RISCs) where they bind single-stranded small interfering RNA (siRNA) and microRNA. They are also important in peptide chain initiation. The argonaute proteins have slicer activity and contain N-terminal PAZ (PIWI/Argonaute/Zwille) domains and C-terminal piwi domains.

Subjects: Medicine and Health.

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