aryl hydrocarbon receptor

Quick Reference

A cytosolic protein (~800 aa) with a basic helix–loop–helix motif that binds a range of aryl hydrocarbons and dioxin and is then translocated to the nucleus where it forms a dimer with ARNT and binds to the xenobiotic response element. The receptor plays an important role in the closure of the ductus venosus and when activated and translocated to the nucleus affects immune, endocrine, reproductive, developmental, cardiovascular, and central nervous system functions.

Subjects: Medicine and Health.

Reference entries