A group of enzymes that will hydrolyse sulphate esters of aromatic substrates. Aryl sulphatase A (EC 220.127.116.11, 507 aa) is a lysosomal enzyme that hydrolyses cerebroside 3-sulphate and is deficient in metachromatic leucodystrophy. Aryl sulphatase B (N-acetylgalactosamine 4-sulphatase, EC 18.104.22.168, 533 aa) is involved in lysosomal hydrolysis of glycosaminoglycans and is deficient in Maroteaux–Lamy syndrome. Aryl sulphatase C (steroid sulphatase, EC 22.214.171.124, 583 aa) hydrolyses several precursors for oestrogens, androgens, and cholesterol. Mutations in the gene causes X-linked ichthyosis. X-linked recessive chondrodysplasia punctata is caused by mutation in aryl sulphatase E (ARSE, 594 aa), the gene for which is located near those for arylsulphatases D and F. See multiple sulphatase deficiency.
Subjects: Medicine and Health — Chemistry.