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A membrane-associated mucin (ascites sialoglycoprotein, mucin-4, 2169 aa) that is proteolytically processed into α and β chains and can be secreted. It has anti-adhesive properties and may play a role in tumour progression, acting as an intramembrane ligand for ErbB2 (see epidermal growth factor) which represses apoptosis and stimulates proliferation.

Subjects: Medicine and Health.

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