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A serine/threonine kinase (apoptosis signal-regulating kinase, mitogen-activated protein kinase kinase kinase 5, MAPKKK5, 1374 aa) that is up-regulated under conditions of cellular stress and activates MAP kinases MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases and cause apoptosis.

Subjects: Medicine and Health.

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