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'ataxin' can also refer to...



Elucidation of ataxin-3 and ataxin-7 function by integrative bioinformatics

Proteotoxic stress increases nuclear localization of ataxin-3

The impact of ataxin-1-like histidine insertions on polyglutamine aggregation

Distribution of ataxin-7 in normal human brain and retina

Ataxin-7 associates with microtubules and stabilizes the cytoskeletal network

Ataxin-2 intermediate-length polyglutamine expansions in European ALS patients

A cell-based screen for modulators of ataxin-1 phosphorylation

Nuclear Localization of the Spinocerebellar Ataxia Type 7 Protein, Ataxin-7

Silencing ataxin-3 mitigates degeneration in a rat model of Machado–Joseph disease: no role for wild-type ataxin-3?

Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3

Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado–Joseph disease

Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction

Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells

Site-specific mutagenesis in a homogeneous polyglutamine tract: application to spinocerebellar ataxin-3

Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease

N-terminal ataxin-3 causes neurological symptoms with inclusions, endoplasmic reticulum stress and ribosomal dislocation

Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation


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A group of proteins that are defective in various forms of spinocerebellar ataxia (SCA) because of expanded numbers of trinucleotide (CAG) repeats (polyglutamine repeats). Ataxin 1 (815 aa), defective in SCA1, binds RNA and may be involved in RNA metabolism. Ataxin 2 (1313 aa) is defective in SCA2. Ataxin 3 (Machado–Joseph disease protein 1, 376 aa) defective in SCA3, represses transcription by interacting with transcriptional regulators and binding to histones. Ataxin 7 (892 aa), defective in SCA7, is a component of the STAGA transcription coactivator-HAT complex. Ataxin 10 (475 aa) is defective in SCA10. Ataxin 1-like (brother of ataxin-1, BOAT, 689 aa) will suppress the cytotoxicity of ataxin 1 in SCA1. Ataxin-7-like protein 1 (833 aa) is known, but not its function. Ataxin-7-like protein 3 (347 aa) is part of the SAGA transcription regulatory complex.

Subjects: Chemistry — Medicine and Health.

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