A family of centrosomal serine/threonine kinases (aurora A, B, and C) that are essential for spindle assembly, centrosome maturation, chromosomal segregation and cytokinesis during mitosis. Abnormalities in the mitotic process through overexpression/amplification of aurora kinase have been linked to genomic instability. Overexpression of aurora kinases occurs in a wide range of tumours and has been implicated in oncogenic transformation. Aurora B (AIM-1, 344 aa) may be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis. Inhibitors may have potential as antitumour drugs. See HEF1; TACCs.
Subjects: Medicine and Health.