Overview

aurora kinases


'aurora kinases' can also refer to...

aurora kinases

aurora B kinase

Characterization of a Splicing Variant of Plant Aurora Kinase

Live Cell Imaging Reveals Plant Aurora Kinase Has Dual Roles During Mitosis

Non-coding murine centromeric transcripts associate with and potentiate Aurora B kinase

Expression and characterization of three Aurora kinase C splice variants found in human oocytes

Copy number increase of aurora kinase A in colorectal cancers: a correlation with tumor progression

Quantitation of Aurora Kinase A Gene Copy Number in Urine Sediments and Bladder Cancer Detection

Identification of a new recurrent Aurora kinase C mutation in both European and African men with macrozoospermia

Regulation of spindle and chromatin dynamics during early and late stages of oocyte maturation by aurora kinases

The centrosomal kinase Aurora‐A/STK15 interacts with a putative tumor suppressor NM23‐H1

A phase I dose escalation study of AT9283, a small molecule inhibitor of aurora kinases, in patients with advanced solid malignancies

Clinical evaluation of AZD1152, an i.v. inhibitor of Aurora B kinase, in patients with solid malignant tumors

P-0025CELL CYCLE INTERFERENCE CONTRIBUTES TO THE ANTICANCER SYNERGY BETWEEN RADIOTHERAPY AND AURORA KINASE INHIBITOR VE-465 IN HEPATOCELLULAR CARCINOMA

Novel pyrimidine-2,4-diamine derivative suppresses the cell viability and spindle assembly checkpoint activity by targeting Aurora kinases

Overcoming CML acquired resistance by specific inhibition of Aurora A kinase in the KCL-22 cell model

Icaritin suppresses development of neuroendocrine differentiation of prostate cancer through inhibition of IL-6/STAT3 and Aurora kinase A pathways in TRAMP mice

ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A: phosphorylation on Ser625 is essential to spindle formation and mitosis

The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population

 

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A family of centrosomal serine/threonine kinases (aurora A, B, and C) that are essential for spindle assembly, centrosome maturation, chromosomal segregation and cytokinesis during mitosis. Abnormalities in the mitotic process through overexpression/amplification of aurora kinase have been linked to genomic instability. Overexpression of aurora kinases occurs in a wide range of tumours and has been implicated in oncogenic transformation. Aurora B (AIM-1, 344 aa) may be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis. Inhibitors may have potential as antitumour drugs. See HEF1; TACCs.

Subjects: Medicine and Health.


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