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A protein (BRCA1-associated RING domain protein 1, EC 6.3.2.-, 777 aa) that forms a heterodimeric complex with BRCA1 that mediates ubiquitin E3 ligase activity and coordinates a range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation. Also forms a heterodimer with CSTF1/CSTF-50, which modulates mRNA processing. Has been reported to have tumour suppressive functions independent of BRCA1.

Subjects: Medicine and Health — Chemistry.

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