BAR proteins

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A superfamily of adaptor proteins (BIN1/amphiphysin/Rvs domain proteins) with a common conserved N-terminal BAR domain, that appear to integrate signal transduction pathways that regulate membrane dynamics, the F-actin cytoskeleton, and nuclear processes. They all bind to membranes but differ in their preferences for membrane curvature. BAR/N-BAR modules bind to membranes of high positive curvature, F-BAR modules bind to a different range of positive membrane curvatures and I-BAR modules bind to negatively curved membranes. BIN1 (see amphiphysin) interacts with and inhibits the oncogenic properties of myc. BIN2 (546 aa) is mostly found in haematopoietic tissues, lacks tumour suppressor functions, and interacts with BIN1, but not amphiphysin. BIN3 (253 aa) has only the BAR domain and is widely expressed. (Rvs is a yeast protein.)

http://www.endocytosis.org/BARdomains/BARs.html Additional information on the BAR superfamily.

Subjects: Medicine and Health.

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