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A protein (320 aa) found in the basolateral membranes of renal tubules and in epithelia of the inner ear that functions as an essential β subunit for chloride channels CLCKNA and CLCKNB. It enhances insertion into the plasma membrane and regulates the permeation and gating of the channel. Mutations can cause Bartter's syndrome type 4 in which there is impaired renal ion absorption and sensorineural deafness.

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